· ·

The spice that prevents fluoride from destroying your brain


Fluoride is found everywhere today, from antibiotics to drinking water, no stick pans to toothpaste, making exposure inevitable. All the more reason why new research proving this common spice can prevent fluoride damage is so promising!

Fluoride's neurotoxicity has been the subject of academic debate for decades, and now a matter of increasingly impassioned controversy among the general public, as well. From 'conspiracy theories' about it being first used in drinking water in Russian and Nazi concentration camps to chemically lobotomize captives, to its now well-known IQ lowering properties, to its ability to enhance the calcification of the pineal gland – the traditional 'seat of the soul' – many around the world, and increasingly in the heavily fluoridated regions of the United States, are starting to organize at the local and statewide level to oust this ubiquitous toxicant from municipal drinking water.

Now, a new study published in the Pharmacognosy Magazine titled, "Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence," adds experimental support to the suspicion that fluoride is indeed a brain-damaging substance, also revealing that a natural spice-derived protective agent against the various health effects associated with this compound is available.

The study was authored by researchers from the Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India, who have spent the past decade investigating the mechanisms through which fluoride induces severe neurodegenerative changes in the mammalian brain, particularly in cells of the hippocampus and cerebral cortex.

The study opens by describing the historical backdrop for concern about fluoride's significant and wide ranging toxicity:

"Fluoride (F) is probably the first inorganic ion which drew attention of the scientific world for its toxic effects and now the F toxicity through drinking water is well-recognized as a global problem. Health effect reports on F exposure also include various cancers, adverse reproductive activities, cardiovascular, and neurological diseases. [1,2]"

The study focused on fluoride induced neurotoxicity, identifying excitoxicity (stimulation of the neuron to the point of death) and oxidative stress as the two main drivers of neurodegeneration.  It has been observed that subjects with the condition known as fluorosis, a mottling of tooth enamel caused by excessive exposure to fluoride during tooth development, also have neurodegenerative changes associated with a form of oxidative stress known as lipid peroxidation (rancidity). Excess lipid peroxidation in the brain can lead to a decrease in total brain phospholipid content. Owing to these well-known mechanisms of fluoride associated neurotoxicity and neurodegeneration, the researchers identified the primary polyphenol in the spice turmeric — known as curcumin – as an ideal agent worth testing as a neuroprotective substance

Previous research on curcumin indicates that it is capable of activing as an antioxidant in 3 distinct ways by protecting against: 1) singlet oxygen 2) hyrodxyl radicals and 3) superoxide radical damage. Also, curcumin appears to raise endogenous glutathione production in the brain, a major antioxidant defense system.

In order to assess the neurotoxic effects of fluoride and prove curcumin's protective role against it, researchers randomly divided up mice into four groups, for 30 days:

  1. Control (no fluoride)
  2. Fluoride (120 ppm): fluoride was given in distilled water drinking water without restriction.
  3. Fluoride (120 ppm/30 mg/kg body weight) + Curcumin: Oral dose of curcumin dissolved in olive oil along with fluoride in drinking water
  4. Curcumin: (30 mg/kg body weight)

In order to ascertain the effect of treatment, the researchers measured the malondialdehyde (MDA) content in the brains of the different treated mice. MDA is a well-known marker of oxidative stress/damage.

As was expected, the fluoride (F) only treatment group showed significantly elevated MDA levels vs. the non-fluoride treated control. The F + Curcumin group saw reduced MDA levels vs. the fluoride only group, demonstrating curcumin's neuroprotective activity against fluoride associated neurotoxicity.

The study concluded,

"Our study thus demonstrate that daily single dose of 120 ppm F result in highly significant increases in the LPO [lipid peroxidation, i.e. brain rancidity] as well as neurodegenerative changes in neuron cell bodies of selected hippocampal regions. Supplementation with curcumin significantly reduce the toxic effect of F to near normal level by augmenting the antioxidant defense through its scavenging property and provide an evidence of having therapeutic role against oxidative stress mediated neurodegeneration."


This is far from the first study to demonstrate curcumin's remarkable brain-saving properties. From the perspective of the primary research alone, there are over two hundred peer-reviewed published studies indicating that curcumin is a neuroprotective agent. On our own turmeric database we have 115 articles proving this statement:Turmeric Protects The Brain.  We have also featured studies on turmeric's ability to protect and restore the brain:

Considering the many chemical insults we face on a daily basis in the post-industrial world, turmeric may very well be the world's most important herb, with over 600 evidence-based health applications.


For more information, please review the following content:


Republished with permission from GreenMedInfo
Written by Sayer Ji

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of The Watchers, GreenMedInfo or their staff.

If you value what we do here, create your ad-free account and support our journalism.


Producing content you read on this website takes a lot of time, effort, and hard work. If you value what we do here, select the level of your support and register your account.

Your support makes this project fully self-sustainable and keeps us independent and focused on the content we love to create and share.

All our supporters can browse the website without ads, allowing much faster speeds and a clean interface. Your comments will be instantly approved and you’ll have a direct line of communication with us from within your account dashboard. You can suggest new features and apps and you’ll be able to use them before they go live.

You can choose the level of your support.

Stay kind, vigilant and ready!

$5 /month

  • Ad-free account
  • Instant comments
  • Direct communication
  • New features and apps suggestions
  • Early access to new apps and features

$50 /year

$10 /month

  • Ad-free account
  • Instant comments
  • Direct communication
  • New features and apps suggestions
  • Early access to new apps and features

$100 /year

$25 /month

  • Ad-free account
  • Instant comments
  • Direct communication
  • New features and apps suggestions
  • Early access to new apps and features

$200 /year

You can also support us by sending us a one-off payment using PayPal:


  1. Answer to Pointedly question. The rate of curcumine inside turmeric is just about 3 to 5 %. The research that givres such results is done with turmeric EXTRACTS that May provide 95 % curcumin. But as far curcumin has a low bioavailability as oral intake, we must take it in capsules with co factors that help to increase such bioavailability. Shobah and other researchers have shown that associations of curcumine with piperine or with gingerols from gingerols may boost oral curcumine bioavailability. Another point is that this curcumine should be extracted without acétone nor éthyle acetate to avoid additional toxic residues that are carcinogens. Few products can provide such quality . in Europe consumers are more aware of such requirements for phyto products. ( exemples of high doses of curcumine with piperine and gingerols : doluperine in Canada from european origin )

  2. Iodine is removed by fluoride; it is fascinating to know that back when the experimental use of fluoride was for 'control', the US put large amounts of iodine in water supplies that mimicked hypothyroidism and 'cured' the condition by using large doses of fluoride in the water.
    One might suspect the overdose of iodine served to justify the fluoridation experiment. Natural spices are wonderful applications to our over experimental society.

  3. Our city water contains 0.7 ppm fluoride. These rats were given 120 ppm fluoride. That is 171 times the does of fluoride in my city water system. Can this test be redone with less fluoride to poison the rats–a test that more correctly replicates the fluoride content of city water systems?

    1. The problem with that is that water is an ingredient in most of the foods and drinks you consume so you are getting fluoride from various sources other than tap water. While I'm sure you're logic is on the right track, one must consider the amount of fluoride being taken in from accumulative sources.

  4. Was the dosage of curcumin 30mg/kg weight daily, or was that the dosage for the 30day period? If that was daily, then expanded to human size we'd have to consume 2.31g of curcumin daily.

    What is the approximate concentration of curcumin within turmeric, i.e. how much turmeric would equate to 30mg of curcumin?

  5. this so great to know. I use turmeric often, I love it's warm spicy flavor. I often combine it with Cumin for Mexican style food. This combo is excellent in soups and stews. If it does everything research says it does, they will probably take it off the shelves and make a medical classification of it. Should we keep quiet?

Leave a Reply to Florianeval Cancel reply

Your email address will not be published.